Dow Institute for Advanced Biological & Animal Research (DIABAR) 2

Welcome To

Dow Institute for Advanced Biological & Animal Research (DIABAR)

DIABAR began its journey as a Laboratory Animal Sciences (LAS) in 2008 comprising a total 4.07Acre area, later on it was upgraded by the establishment of its extension laboratory as Advanced Research Laboratory (ARL) in January 2017. In continuation of innovation various Quality Operation Sections are established includes; Basic Biological Manufacturing Facility (BBMF), Quality Control Laboratory (QC) & Quality Assurance (QA) and Research & Development, all are now collectively working under the umbrella of DIABAR-DUHS. A journey of revolution is going on as an exclusive pre-clinical & toxicological testing service provider and as the basic manufacturer of biologicals in the country.

We are unique in the country as producers of basic biological raw material under the designated facility BBMF. VCPL is a nested facility for the collection and processing of venom to serve as raw material provider and as bio-bank of Big 4 which has been used for the immunization of horses to collect hyperimmunized plasma. Two major projects are our prime targets to improve the health system of the country with the aim to decrease economic burden by indigenous production of biological plants using local strains.

  1. Anti-snake venom (ASV) production against big 4 snakes of Pakistan
  2. Inactivated Rabies Vaccine production under GCF-790 awarded by World Bank.

The DIABAR, is continuously working on the concept of Venom Bank for bio-therapeutics and cosmetics purposes. Due to our running Anti-Snake Venom Project, our prime target is Pakistan’s Big-4 Venoms detailed Venomics, Biological & Toxicological profiles and Therapeutics Index in different animal disease and cell based models, these data is also beneficial for Anti-Snake Venom project indigenously in the country especially Next-Generation anti-snake venom and marketing of snake venom as a raw material, this is first time the Pakistani venom is explored on these aspects, we have completed our data on 4 batches of venom regarding general quality control tests as per our previously approved methods.

Under the entitlement of “DUHS Venom Project BIG-4” with the approval and Agreement of Vice Chancellor, Prof. Dr. Saeed Quraishy, we are designing a series of Projects for pilot studies and applied for different funding agency for conducting comprehensive R&D projects leading to commercialization.

Message from Our Director

Dr. Talat Roome
Director, DIABAR

I am honored to serve as a Director “Dow Institute for Advanced Biological & Animal Research”. DIABAR is a state-of-the-art facility meeting the international standards; it has four major sections ranging from preclinical toxicology testing facility to Research and Development (R&D) section extended to central animal house and a Basic Biological Manufacturing Facility (BBMF) for the translation of R&D projects. Quality control section helps abide by the international standards and guidelines for the production of biological products whereas all logistics and working in DIABAR are strictly regulated by its QMS. We are unique in the country in maintaining a diverse group of experimental animals and a wonderful equine system for the manufacturing of biological products.

Our passion for research facilitates the scientific community from different domains of the health sector; it empowered us to have thought leadership in addressing the health challenges being faced by the country during the worst economic crises. Establishment of the DIABAR is a great addition in the list of country’s most accomplished research and development institutions to deliver results on health and health-related Sustainable Development Goals. Over the past 20 years, we have leveraged our expertise in providing high-quality research and services for research students, academic institutions and other stakeholders in Health and pharmaceuticals.

DIABAR serves a hub of scientific activities; our Advanced Research Laboratory facilitates interdisciplinary research from vast avenues of academia and industry on the other hand Pre- Clinical Toxicological laboratory offers wide range of toxicity testing services using both in-vitro and in-vivo approaches, dedicated experimental animal models are also being used for precise results. We comply with FDA approved protocols and animal ethical guidelines for testing of drugs and natural extracts etc. Quality control section of DIABAR not only fulfills institutional needs rather it outsources its testing facilities. Through our work, we have established strong ties with the government and private sector across the country, and brides‟ strong collaborations with renowned institutions around the globe.

DIABAR also focuses on academia; we strongly encourage youngsters across the country to join us for collaborative research work and training. We also provide experimental 100 class facilities for animal surgical procedures to researchers and faculty members. We also support postgraduate students to carry out their experimental work with the provision of full resources.

Our vision is to strengthen the health and economic sector of the country by indigenous production of biopharmaceutical products including vaccines. Keeping in view the country’s needs, our major projects focus on the production of anti-snake venom against big 4 of Pakistan and manufacturing of inactivated rabies vaccine using local virus strains.

Being a Director of the institute; I constantly encourage and support the DIABAR team to work day and night, I‟m very delighted to follow our honorable Vice Chancellor, Prof. Dr. Muhammad Saeed Quraishy‟s Vision for the betterment of our health system and my self- commitment is to keep serving for the national cause. I‟m quite hopeful to meet the strategic plans of Dow University of Health Sciences by bringing up the quality products at national level as a Basic Biological Manufacturer. We want to bring up the facility as an International Accredited Laboratory with licensing to work as Pre-clinical & Toxicological research and screening service provider using animal models etc., for all this up gradation and to meet aforementioned milestones DUHS has been continuously supporting us to build the infrastructure. Read more

Our Scope

Dow Institute for Advanced Biological & Animal Research (DIABAR) is one of the reputable Institute of Dow University of Health Sciences with the vision of continuous upgradation and innovation in systems and infrastructures. DIABAR is a state-of-the-art facility having four major sections namely Research and Development (R&D), Preclinical Toxicology Testing facility, Basic Biological Manufacturing Facility (BBMF) and Central Animal House. Quality control assures the authenticity of experimental data and products quality, while the Quality Assurance section ensures the implementation of proper SOPs and training of staff. DIABAR is a core facility to execute the interdisciplinary research broadly from R&D level and its translation into Applied Science Projects.

Toxicity testing services help researchers from different domains receive samples of various types from academic Institutions and Industries across the country. Our well trained and highly qualified staff at each section ensure good quality services and research of international standards as evident by the grant of US Patent and enormous publications. So far, we have served different pharmaceutical industries including Medics Pvt. Ltd., Mector Pvt. Ltd, Indus Pharma (Pvt.) Ltd. and Dalda Foods Ltd and Hamdard laboratories Pvt. Ltd. Herbion Pvt. Ltd, Hilton Pharmaceuticals.

We have developed strong National & International collaborations with Aga Khan University Hospital, International Center for Chemical and Biological Sciences (ICCBS), DESTO-BRC, Hamdard University, University of Karachi and Interdisciplinary Research Center in Biomedical Materials (IRCBM), COMSATS University Islamabad Lahore Campus as national collaborators in several research projects. Moreover, the DIABAR is coordinating with the international collaborators and service provider organizations at Chapman University, Irvine, California, USA; Virginia Commonwealth University (VCU) Virginia, USA; The American Type Culture Collection (ATCC; Cell line Bank), Manassas, Virginia, USA; Dept. of Materials Science & Engineering, University of Sheffield, UK; Biomedical Research Center, Qatar University etc. for exchange of knowledge and item provision and data analysis.

We are unique in the country in maintaining a diverse group of experimental animals and a wonderful equine system under continuous monitoring of veterinary doctors for the manufacturing of biological products. Our major project of Anti-snake venom (ASV) production against big 4 snakes is well known in Pakistan as a Basic manufacturer. We are honored to receive the HEC-World Bank funding under GCF-790 project of indigenous inactivated Rabies Vaccine development.

Our

Vision

To be a pre-eminent biological research institution committed to changing and saving lives.

Our

Mission

Providing capacity for advanced research, innovation generating, dissemination of new knowledge of commercial importance and sustaining a mutually productive engagement with the local community.

Our Laboratories & Facilities

Central Animal House Facility

Advanced Research Laboratory

Basic Biological Manufacturing Facility

Toxicology Testing Laboratory

Contact Us

DOW INSTITUTE FOR ADVANCED BIOLOGICAL & ANIMAL RESEARCH (DIABAR)

Call

Phone: +92 21 111 113 847

Ext: 4446, 4435, 4332

Address

Dow University of Health Sciences (Ojha Campus), Karachi-75280